Pyritinol versus Hydergine

Alzheimer’s Research (UK) , 1996, 2/3 (79-84)

ABSTRACT

In this multi-center trial, 100 patients with the diagnosis of senile dementia of the Alzheimer’s type (SDAT) of mild to moderate severity were randomly divided into two treatment groups and, following a placebo wash-out phase, were administered either pyritinol or Hydergine for 12 weeks in a double-blind, randomized parallel comparison. Two measures of cognitive functioning were employed to assess treatment effects. The results indicated that treatment with pyritinol was associated with a significant and continuous improvement in cognitive functioning over the course of the study while treatment with Hydergine was associated with a more modest improvement that tended to plateau early in the treatment phase.